Table 1.
Overview of differentially regulated gene-set groups in appendicitis–appendectomy (AA) mice compared to sham–sham (SS) mice.
| Genes set group | Category | No. of gene-sets | Gene-sets up-regulated in AA mice | |
|---|---|---|---|---|
| 1 | Kegg pathways | KEGG | 150 | 9 |
| c2_kegg.GseaPreranked | ||||
| 2 | Micro RNAs | MIR | 200 | 0 |
| c3_mir.GseaPreranked | ||||
| 3 | Transcription factors | TFT | 579 | 41 |
| c3_tft.GseaPreranked | ||||
| 4 | Biological processes | BP | 536 | 7 |
| c5_bp.GseaPreranked | ||||
| 5 | Others | OTH | 1387 | 209 |
| c2_all.GseaPreranked | ||||
| Total | 2852 | 266 |
The gene-set groups chosen for further evaluation had stringent cut-off values (FDR < 1% and P < 0·001). Using these criteria, there were no gene-sets up-regulated in the SS group. However, 266 gene-sets were up-regulated in the AA group. SS group: sham and sham group; AA group: appendicitis and appendectomy group; FDR: false discovery rate.