Table 4.
Relation of body mass index to hyperplastic polyps only (excluding cases of colorectal adenomas)
| Variable | Body mass index (kg/m2) | P for trend | ||
|---|---|---|---|---|
| ≤24.9 | 25.0–29.9 | ≥30.0 | ||
| Total hyperplastic polyps | ||||
| No. of cases/controls | 52/477 | 68/295 | 55/181 | |
| Age-adjusted OR (95% CI) | 1.0 | 2.13 (1.44–3.16) | 2.82 (1.85–4.30) | <0.0001 |
| Multivariate-adjusted OR (95% CI) | 1.0 | 2.36 (1.55–3.58) | 3.76 (2.35–6.01) | <0.0001 |
| Small hyperplastic polyps | ||||
| No. of cases/controls | 36/477 | 50/295 | 40/181 | |
| Age-adjusted OR (95% CI) | 1.0 | 2.26 (1.43–3.56) | 2.94 (1.81–4.79) | <0.0001 |
| Multivariate-adjusted OR (95% CI) | 1.0 | 2.56 (1.58–4.14) | 4.07 (2.37–6.99) | <0.0001 |
| Large hyperplastic polyps | ||||
| No. of cases/controls | 16/477 | 18/295 | 15/181 | |
| Age-adjusted OR (95% CI) | 1.0 | 1.79 (0.89–3.60) | 2.48 (1.19–5.18) | 0.04 |
| Multivariate-adjusted OR (95% CI) | 1.0 | 1.73 (0.80–3.73) | 3.11 (1.34–7.21) | 0.03 |
| Multiple hyperplastic polyps | ||||
| No. of cases/controls | 11/477 | 31/295 | 24/181 | |
| Age-adjusted OR (95% CI) | 1.0 | 4.62 (2.27–9.38) | 5.74 (2.73–12.1) | <0.0001 |
| Multivariate-adjusted OR (95% CI) | 1.0 | 5.06 (2.34–10.94) | 8.88 (3.87–20.39) | <0.0001 |
| Proximal hyperplastic polyps only | ||||
| No. of cases/controls | 15/477 | 15/295 | 11/181 | |
| Age-adjusted OR (95% CI) | 1.0 | 1.57 (0.75–3.28) | 1.84 (0.82–4.13) | 0.46 |
| Multivariate-adjusted OR (95% CI) | 1.0 | 2.19 (0.98–4.90) | 3.59 (1.42–9.12) | 0.05 |
| Distal hyperplastic polyps only | ||||
| No. of cases/controls | 18/477 | 31/295 | 20/181 | |
| Age-adjusted OR (95% CI) | 1.0 | 2.83 (1.55–5.16) | 2.95 (1.52–5.73) | 0.0005 |
| Multivariate-adjusted OR (95% CI) | 1.0 | 2.98 (1.57–5.64) | 3.87 (1.87–7.97) | 0.0001 |
| Rectal hyperplastic polyps only | ||||
| No. of cases/controls | 15/477 | 11/295 | 16/181 | |
| Age-adjusted OR (95% CI) | 1.0 | 1.19 (0.54–2.65) | 2.95 (1.42–6.16) | 0.01 |
| Multivariate-adjusted OR (95% CI) | 1.0 | 1.04 (0.44–2.44) | 2.83 (1.22–6.56) | 0.03 |
Multivariate-adjusted models included age (5-year categories), study center (4 categories), race or ethnic group (White; Black; and Asian, Hispanic, and other combined), family history of colorectal cancer or colorectal polyp (yes or no), history of colonoscopy or barium enema in the previous 10 years (yes or no), history of flexible sigmoidoscopy in the previous 5 years (yes or no), smoking (never; former; current smoker of <20 cigarettes per day; and current smoker of ≥20 cigarettes per day), aspirin use (yes or no), menopausal status (yes or no), current menopausal hormone therapy (yes or no), physical activity (low; intermediate; high), and intakes of alcohol (grams/day; continuous), red meat (grams/day; continuous), and vitamin D (I.U./day; continuous).