Table 5.
Relation of body mass index to the presence of both colorectal adenomas and hyperplastic polyps
| Variable | Body mass index (kg/m2) | P for trend | ||
|---|---|---|---|---|
| ≤24.9 | 25.0–29.9 | ≥30.0 | ||
| Total adenomas and hyperplastic polyps | ||||
| No. of cases/controls | 21/477 | 31/295 | 23/181 | |
| Age-adjusted OR (95% CI) | 1.0 | 2.35 (1.31–4.19) | 2.88 (1.54–5.39) | 0.004 |
| Multivariate-adjusted OR (95% CI) | 1.0 | 2.19 (1.18–4.07) | 2.84 (1.41–5.72) | 0.02 |
| Nonadvanced adenomas and any hyperplastic polyp | ||||
| No. of cases/controls | 17/477 | 17/295 | 18/181 | |
| Age-adjusted OR (95% CI) | 1.0 | 1.64 (0.82–3.27) | 2.85 (1.42–5.69) | 0.02 |
| Multivariate-adjusted OR (95% CI) | 1.0 | 1.52 (0.73–3.16) | 2.73 (1.25–5.94) | 0.08 |
| Advanced adenomas and any hyperplastic polyp | ||||
| No. of cases/controls | 4/477 | 14/295 | 5/181 | |
| Age-adjusted OR (95% CI) | 1.0 | 5.38 (1.73–16.71) | 3.09 (0.81–11.90) | 0.08 |
| Multivariate-adjusted OR (95% CI) | 1.0 | 5.58 (1.56–19.95) | 3.34 (0.74–15.04) | 0.14 |
| Proximal adenomas only and any hyperplastic polyp | ||||
| No. of cases/controls | 8/477 | 15/295 | 17/181 | |
| Age-adjusted OR (95% CI) | 1.0 | 3.00 (1.25–7.21) | 5.45 (2.29–12.98) | <0.0001 |
| Multivariate-adjusted OR (95% CI) | 1.0 | 2.80 (1.13–6.96) | 4.63 (1.81–11.83) | 0.003 |
| Distal/rectal adenomas only and any hyperplastic polyp | ||||
| No. of cases/controls | 12/477 | 8/295 | 2/181 | |
| Age-adjusted OR (95% CI) | 1.0 | 1.09 (0.44–2.71) | 0.45 (0.10–2.06) | 0.28 |
| Multivariate-adjusted OR (95% CI) | 1.0 | 1.14 (0.39–3.33) | 0.37 (0.06–2.45) | 0.27 |
| Small hyperplastic polyps and any adenoma | ||||
| No. of cases/controls | 16/477 | 17/295 | 15/181 | |
| Age-adjusted OR (95% CI) | 1.0 | 1.73 (0.86–3.49) | 2.47 (1.19–5.16) | 0.01 |
| Multivariate-adjusted OR (95% CI) | 1.0 | 1.72 (0.81–3.67) | 2.92 (1.27–6.69) | 0.01 |
| Large hyperplastic polyps and any adenoma | ||||
| No. of cases/controls | 5/477 | 14/295 | 8/181 | |
| Age-adjusted OR (95% CI) | 1.0 | 4.38 (1.55–12.41) | 4.16 (1.32–13.09) | 0.12 |
| Multivariate-adjusted OR (95% CI) | 1.0 | 4.68 (1.49–14.74) | 4.52 (1.27–16.10) | 0.32 |
| Proximal hyperplastic polyps only and any adenoma | ||||
| No. of cases/controls | 7/477 | 7/295 | 6/181 | |
| Age-adjusted OR (95% CI) | 1.0 | 1.53 (0.53–4.45) | 2.08 (0.68–6.37) | 0.51 |
| Multivariate-adjusted OR (95% CI) | 1.0 | 1.17 (0.37–3.72) | 1.59 (0.45–5.64) | 0.89 |
| Distal/rectal hyperplastic polyps only and any adenoma | ||||
| No. of cases/controls | 10/477 | 20/295 | 12/181 | |
| Age-adjusted OR (95% CI) | 1.0 | 3.31 (1.52–7.23) | 3.31 (1.39–7.89) | 0.005 |
| Multivariate-adjusted OR (95% CI) | 1.0 | 3.36 (1.46–7.71) | 3.66 (1.40–9.58) | 0.005 |
Multivariate-adjusted models included age (5-year categories), study center (4 categories), race or ethnic group (White; Black; and Asian, Hispanic, and other combined), family history of colorectal cancer or colorectal polyp (yes or no), history of colonoscopy or barium enema in the previous 10 years (yes or no), history of flexible sigmoidoscopy in the previous 5 years (yes or no), smoking (never; former; current smoker of <20 cigarettes per day; and current smoker of ≥20 cigarettes per day), aspirin use (yes or no), menopausal status (yes or no), current menopausal hormone therapy (yes or no), physical activity (low; intermediate; high), and intakes of alcohol (grams/day; continuous), red meat (grams/day; continuous), and vitamin D (I.U./day; continuous).