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. 2011 Aug 9;105(6):824–832. doi: 10.1038/bjc.2011.283

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Copyright © 2011 Cancer Research UK

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Effect of MMP inhibitors and siRNA on A431 tumour cell invasion. (A) RT–PCR detection of MT1-MMP and MMP2 expression in A431 SCC cells and HaCaT non-neoplastic keratinocytes. (B) Matrigel invasion assay. BB94 and TIMP-2 significantly blocked A431 tumour cell invasion of Matrigel at 48 h, whereas inhibition by TIMP-1 was insignificant. (C) Treatment with MT1-MMP siRNA downregulated the expression of 60 kDa bands of MT1-MMP. (D) Tumour cell invasion of Matrigel was significantly suppressed by transfection of MT1-MMP siRNA (0.01 pmol ml⁻¹) at 48 and 72 h. Data in (B) and (D) are shown as mean±s.e.m. (n=4). ^*P<0.01 by Student's t-test. G3PDH=glyceraldehydes-3-phosphate dehydrogenase.