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| Schedule | Cohort | Dacarbazine (mg m−2) | Lomeguatrib (mg per day) | No. of patients |
|---|---|---|---|---|
| Aa | 1 | 500 | 40 | 3 |
| 2 | 500 | 80 | 3 | |
| 3 | 600 | 80 | 3 | |
| 4 | 700 | 80 | 3 | |
| 5 | 800 | 80 | 6 | |
| Bb | 6 | 700 | 80 | 4 |
| 7 | 600 | 80 | 6 | |
| 8 | 500 | 80 | 3 | |
| 9 | 400 | 80 | 9 |
Schedule A: once daily dosing of lomeguatrib on days 1–5 of each 21-day cycle.
Schedule B: twice daily dosing of lomeguatrib on days 1–10 of each 2-day cycle.
