Table 2. Summary results for the six most significant SNPs in all EPICOLON phases.
| Discovery | Replication | Overall | ||||||
|---|---|---|---|---|---|---|---|---|
| SNP | Gene | Test | OR (95% CI) | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value |
| rs1444601 | TOPBP1 | Geno | 0.77 (0.59–1.00) | 0.93 (0.76–1.14) | 0.88 (0.75–1.03) | |||
| 0.69 (0.42–1.13) | 0.087 | 0.64 (0.43–0.97) | 0.097 | 0.65 (0.48–0.89) | 0.015 | |||
| Allelic | 0.80 (0.65–0.98) | 0.028 | 0.86 (0.74–1.01) | 0.070 | 0.84(0.75–0.95) | 0.0054 | ||
| Dom | 0.76 (0.59–0.97) | 0.030 | 0.88 (0.73–1.07) | >0.1 | 0.84 (0.72–0.98) | 0.023 | ||
| Rec | 0.77 (0.47–1.24) | 0.279 | 0.66 (0.45–0.99) | 0.041 | 0.69 (0.51–0.94) | 0.016 | ||
| rs13088006 | CDV3 | Geno | 1.05 (0.80–0.37) | 0.83 (0.68–1.03) | 0.92 (0.78–1.08) | |||
| 0.55 (0.32–0.95) | 0.067 | 0.73 (0.46–1.16) | >0.1 | 0.66 (0.47–0.92) | 0.043 | |||
| Allelic | 0.88 (0.71–1.08) | 0.222 | 0.84 (0.71–0.99) | 0.042 | 0.87 (0.76–0.98) | 0.025 | ||
| Dom | 0.96 (0.74–1.24) | 0.715 | 0.82 (0.67–0.99) | 0.049 | 0.88 (0.75–1.02) | 0.098 | ||
| Rec | 0.54 (0.31–0.92) | 0.022 | 0.78 (0.49–1.23) | >0.1 | 0.98 (0.48–0.95) | 0.022 | ||
| rs939453 | ARMC8 | Geno | 0.68 (0.51–0.90) | 1.10 (0.88–1.38) | 1.10 (0.71–1.01) | |||
| 0.62 (0.43–0.89) | 0.017 | 1.07 (0.81–1.41) | >0.1 | 0.79 (0.64–0.98) | 0.068 | |||
| Allelic | 0.78 (0.65–0.93) | 0.0056 | 0.96 (0.84–1.1) | >0.1 | 0.89 (0.80–0.99) | 0.025 | ||
| Dom | 1.47 (1.11–1.93) | 0.0062 | 0.91 (0.74–1.13) | >0.1 | 0.83 (0.71–0.98) | 0.27 | ||
| Rec | 0.77 (0.56–1.04) | 0.091 | 0.99 (0.78–1.25) | >0.1 | 0.88 (0.73–1.05) | 0.163 | ||
| rs1131597 | SLCO2A1 | Geno | 0.77 (0.59–1.01) | 0.97 (0.79–1.19) | 0.97 (0.76–1.04) | |||
| 0.47 (0.31–0.72) | 0.0015 | 1.07 (0.79–1.47) | >0.1 | 0.80 (0.63–1.02) | >0.1 | |||
| Allelic | 0.71 (0.59–0.86) | 0.00038 | 1.02 (0.88–1.17) | >0.1 | 0.89 (0.80–0.99) | 0.043 | ||
| Dom | 0.70 (0.54–0.90) | 0.005 | 0.99 (0.82–1.20) | >0.1 | 0.88 (0.75–1.01) | 0.068 | ||
| Rec | 0.54 (0.36–0.81) | 0.0026 | 1.09 (0.81–1.46) | >0.1 | 0.85 (0.67–1.07) | 0.164 | ||
| rs10934954 | PIK3R4 | Geno | 1.13 (0.86–1.47) | 0.93 (0.75–1.15) | 1.01 (0.85–1.18) | |||
| 1.95 (1.09–3.51) | 0.068 | 1.25 (0.79–1.98) | >0.1 | 1.50 (1.05–2.13) | 0.081 | |||
| Allelic | 1.25 (1.01–1.54) | 0.042 | 1.01 (0.87–1.15) | >0.1 | 1.10 (0.97–1.25) | >0.1 | ||
| Dom | 1.21 (0.94–1.56) | 0.146 | 0.97 (0.79–1.18) | >0.1 | 1.06 (0.91–0.24) | 0.450 | ||
| Rec | 1.87 (1.05–3.34) | 0.031 | 1.28 (0.82–2.02) | >0.1 | 1.49 (1.05–2.12) | 0.025 | ||
| rs2071387 | RBP1 | Geno | 1.17 (0.89–1.55) | 1.02 (0.82–1.26) | 1.04 (0.88–1.23) | |||
| 0.38 (0.17–0.87) | 0.023 | 1.40 (0.81–2.43) | >0.1 | 0.57 (0.36–0.90) | 0.034 | |||
| Allelic | 0.95 (0.75–1.20) | 0.672 | 0.93 (0.78–1.11) | >0.1 | 0.93 (0.81–1.07) | >0.1 | ||
| Dom | 1.06 (0.81–1.39) | 0.662 | 0.95 (0.77–1.17) | >0.1 | 0.98 (0.84–1.15) | >0.1 | ||
| Rec | 0.37 (0.16–0.83) | 0.012 | 0.72 (0.42–1.24) | >0.1 | 0.56 (0.36–0.88) | 0.010 |
Abbreviations: CI=confidence interval; Dom=dominant; Geno=genotypic; OR=odds ratio; Rec=recessive; SNP=single-nucleotide polymorphism.
ORs and unadjusted P-values are shown for discovery, replication and overall phases for each of them. Significant P-values are depicted in bold.