Table 3. Association of known prostate cancer risk SNPs in the Ashkenazi Jewish population.
|
Unadjusted
|
Age adjusted
|
|||||||
|---|---|---|---|---|---|---|---|---|
| SNP | Chr. | Gene | Alleles (Maj/Min) | OR (95% CI) | P | OR (95% CI) | P | Power |
| rs721048 | 2 | EHBP1 | G/A | 1.09 (0.93–1.27) | 0.3 | 1.16 (0.94–1.44) | 0.17 | 0.37 |
| rs2660753 | 3 | CHMP2B; POU1F1 | C/T | 1.04 (0.91–1.19) | 0.55 | 0.98 (0.82–1.16) | 0.78 | 0.65 |
| rs9364554 | 6 | SLC22A3; SLC22A2; LPAL2; LPA | C/T | 1.1 (0.96–1.27) | 0.19 | 1.01 (0.83–1.22) | 0.94 | 0.54 |
| rs10486567 | 7 | JAZF1 | G/A | 0.98 (0.86–1.11) | 0.71 | 1.14 (0.97–1.35) | 0.12 | 1 |
| rs6465657 | 7 | LMTK2; BHLHB8 | T/C | 1.14 (1.01–1.27) | 0.026 | 1.12 (0.96–1.3) | 0.15 | 0.47 |
| rs7008482 | 8 | — | T/G | 0.84 (0.74–0.94) | 0.0036 | 0.87 (0.74–1.02) | 0.08 | 1 |
| rs1016343 | 8 | — | C/T | 1.24 (1.07–1.42) | 0.0031 | 1.19 (0.98–1.43) | 0.075 | 0.98 |
| rs13254738 | 8 | — | A/C | 1.19 (1.06–1.33) | 0.0039 | 1.15 (0.98–1.34) | 0.086 | 0.42 |
| rs16901979 | 8 | — | C/A | 1.01 (0.69–1.48) | 0.94 | 0.94 (0.58–1.53) | 0.8 | 0.77 |
| rs6983267 | 8 | — | G/T | 0.81 (0.72–0.91) | 0.00026 | 0.83 (0.72–0.97) | 0.018 | 0.97 |
| rs7000448 | 8 | — | C/T | 1.2 (1.07–1.34) | 0.0021 | 1.18 (1.01–1.37) | 0.033 | 0.61 |
| rs4242382 | 8 | — | G/A | 1.31 (1.05–1.62) | 0.015 | 1.63 (1.21–2.21) | 0.0013 | 0.75 |
| rs4242384 | 8 | — | A/C | 1.24 (0.92–1.68) | 0.16 | 1.61 (1.09–2.36) | 0.017 | 0.95 |
| rs7920517 | 10 | MSMB | G/A | 0.92 (0.82–1.03) | 0.17 | 0.84 (0.72–0.98) | 0.026 | 0.92 |
| rs10993994 | 10 | MSMB | T/C | 0.89 (0.79–1) | 0.047 | 0.84 (0.72–0.98) | 0.022 | 0.97 |
| rs4962416 | 10 | CTBP2 | T/C | 1 (0.89–1.13) | 0.96 | 0.95 (0.81–1.11) | 0.51 | 0.82 |
| rs7931342 | 11 | — | G/T | 0.8 (0.7–0.9) | 0.0003 | 0.79 (0.67–0.92) | 0.0035 | 0.82 |
| rs10896449 | 11 | — | G/A | 0.8 (0.71–0.91) | 0.00044 | 0.8 (0.68–0.93) | 0.0054 | 0.99 |
| rs4430796 | 17 | TCF2 | G/A | 1.17 (1.04–1.31) | 0.0092 | 1.19 (1.02–1.39) | 0.023 | 0.95 |
| rs7501939 | 17 | TCF2 | C/T | 0.9 (0.8–1.01) | 0.065 | 0.95 (0.81–1.11) | 0.53 | 0.89 |
| rs1859962 | 17 | — | G/T | 0.89 (0.77–1.04) | 0.14 | 0.92 (0.76–1.11) | 0.4 | 0.83 |
| rs2735839 | 19 | KLK2; KLK3 | G/A | 0.91 (0.79–1.06) | 0.24 | 0.89 (0.73–1.08) | 0.24 | 0.73 |
| rs5945572 | X | NUDT11; NUDT10 | G/A | 1.3 (1.08–1.55) | 0.0049 | 1.17 (0.92–1.48) | 0.21 | 0.87 |
Abbreviations: alleles=major/minor alleles; Chr.=chromosome; gene=nearby gene as reported in the cited literature; min=minor; maj=major; OR=odds ratio for the minor allele; SNP=single nucleotide polymorphism; 95% CI=95% confidence interval.
SNPs in bold are significant at a nominal P<0.05 either without age adjustment, with age adjustment or both. Underlined P-values are significant at a false discovery rate of 5%.