Table 2. Cox regression analysis of patient features, NHS Trust trial entry and the patient's receipt of chemotherapy on overall survival.

	Total patients (N=7782)	Deaths (N=6981)	%a	Unadjusted HR	Adjusted HRb	P-value c
Sex
Male	4206	3838	91			<0.001
Female	3576	3143	88	0.84 (0.80, 0.88)	0.86 (0.82, 0.90)
Age quintile (years)
1 (30–62)	2161	1859	86			<0.001
2 (63–69)	1917	1731	90	1.22 (1.14, 1.30)	1.12 (1.04, 1.21)
3 (70–75)	1757	1561	89	1.31 (1.23, 1.40)	1.20 (1.11, 1.30)
4 (76–80)	1159	1079	93	1.62 (1.51, 1.75)	1.31 (1.19, 1.44)
5 (81–101)	788	751	95	2.07 (1.90, 2.25)	1.47 (1.32, 1.64)
Performance status
PS 0	975	772	79			<0.001
PS 1	1919	1653	86	1.39 (1.28, 1.52)	1.34 (1.24, 1.45)
PS 2	1437	1344	94	2.19 (2.01, 2.40)	1.83 (1.67, 2.00)
PS 3	868	847	98	3.82 (3.46, 4.21)	2.65 (2.36, 2.99)
PS 4	269	265	99	8.63 (7.40, 9.95)	5.01 (4.05, 6.19)
Missing	2314	2100	91	1.86 (1.71, 2.02)	1.63 (1.50, 1.77)
Stage
Limited	1319	1043	79			0.001
Extensive	3053	2894	95	2.45 (2.28, 2.63)	2.07 (1.92, 2.25)
Missing	3410	3044	89	1.74 (1.62, 1.87)	1.43 (1.31, 1.57)
Townsend quintile
1 (Most affluent)	1075	947	88			0.341
2	1378	1234	90	1.04 (0.96, 1.13)	1.07 (0.98, 1.17)
3	1523	1365	90	1.08 (0.99, 1.17)	1.07 (0.97, 1.17)
4	1650	1490	90	1.05 (0.97, 1.14)	1.07 (0.98, 1.18)
5 (Least affluent)	2138	1929	90	1.05 (0.97, 1.13)	1.07 (0.96, 1.19)
Missing	18	16	89	1.13 (0.69, 1.85)	1.52 (1.15, 2.02)
Ethnic group
White	6015	5439	90			0.422
Black	31	26	84	0.71 (0.49, 1.05)	0.79 (0.56, 1.11)
Asian	396	344	87	1.06 (0.95, 1.19)	1.01 (0.88, 1.15)
Mixed	14	11	79	0.69 (0.38, 1.24)	0.78 (0.47, 1.31)
Other	37	32	87	1.00 (0.71, 1.42)	0.84 (0.46, 1.52)
Missing	1289	1129	88	1.00 (0.93, 1.06)	1.04 (0.94, 1.14)
Charlson index
0	3466	3015	87			<0.001
1	1483	1301	88	1.23 (1.15, 1.32)	1.07 (1.01, 1.14)
2 or 3	1080	967	90	1.35 (1.25, 1.45)	1.11 (1.02, 1.22)
4+	1753	1698	97	2.09 (1.97, 2.22)	1.62 (1.49, 1.77)
Chemotherapy
No	2967	2825	95			<0.001
Yes	4815	4156	86	0.43 (0.41, 0.45)	0.51 (0.46, 0.56)
Trial entry (%)
<5	5282	4739	90			0.83
>5	2500	2242	90	0.96 (0.91, 1.01)	0.99 (0.88, 1.10)

Abbreviations: HR=hazard ratio; NHS=National Health Service.

^aPercentage of patients from each subgroup who have died.

^bHR adjusted for all other variables in the table. Analysis clustered by the NHS Trust features.

^cAll non-binary variables are tested for trend except ethnicity, which is a likelihood ratio test.

All missing values were removed prior to the calculation of probability.

A total of 63 patients had a date of diagnosis on or before their date of death, and were excluded from survival analyses (N=7782).