Figure 5.

Myc-induced tumorigenesis is accelerated by ARF loss. The genotypes of the mice are indicated next to the survival curves and the number of mice in each group are denoted by the n values. Thin vertical lines indicate ages of surviving mice. The average life spans of ARF^+/+ Eμ–myc and ARF^+/− Eμ–myc mice were 30 and 11 weeks, respectively. ARF^−/− Eμ–myc animals were underrepresented because a fraction died soon after birth. Of those that survived weaning and were followed prospectively, their average survival was less than 7 weeks. Lymphoma was documented in all the animals.