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. 2011 Sep 1;2:55. doi: 10.3389/fphys.2011.00055

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Copyright © 2011 Streeter, Al-Magableh, Hart and Badoer.

This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.

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Changes in mean arterial pressure (MAP), heart rate (HR), and lumbar sympathetic nerve activity (LSNA) following vehicle (n = 13 for MAP and HR and n = 6 for LSNA) and amino-oxyacetate (AOA; 0.1–1.0 nmol/side) and hydroxylamine (HA; 0.2–2.0 nmol/side; n = 8 for MAP and HR; and n = 5 for LSNA) microinjected into the rostral ventrolateral medulla in WKY rats. AOA and HA are inhibitors of the enzyme cystathionine-β-synthase. Different shaded bars represent a different dose of drug as indicated.