Table 1.
Resting discharge rates and patterned activity in GP, STN, and EP (n = 9 dystonic, 9 controls).
| Patterna | Rates | Asymmetry indexb | Burst per minutec | % of spikes in burst |
|---|---|---|---|---|
| GLOBUS PALLIDUS (N = 4 CONTROLS, 4 DYSTONICS) | ||||
| Normals (74) | 41.2 ± 17.1 | 0.72 ± 0.22 | 8.2 ± 13.8 | 1.4 ± 2.5 |
| Regular (61) | 48.3 ± 18.6 | 0.78 ± 0.16 | 9.0 ± 13.5 | 1.5 ± 2.4 |
| Irregular (12) | 16.6 ± 6.4 | 0.36 ± 0.15 | 0.5 ± 1.4 | 0.2 ± 0.4 |
| Dystonics (49) | 11.3 ± 7.9* | 0.07 ± 0.07* | 41.3 ± 57.0* | 35.0 ± 37.8* |
| Bursty (24) | 13.7 ± 9.9 | 0.04 ± 0.03 | 76.5 ± 60.3 | 65.1 ± 28.3 |
| Irregular (22) | 8.2 ± 3.2 | 0.10 ± 0.10 | 2.9 ± 4.3 | 2.1 ± 2.6 |
| SUBTHALAMUS (N = 5 CONTROLS, 4 DYSTONICS) | ||||
| Normals (45) | 27.3 ± 9.9 | 0.53 ± 0.30 | 5.6 ± 8.0 | 1.4 ± 2.0 |
| Regular (18) | 43.0 ± 13.3 | 0.80 ± 0.20 | 4.7 ± 5.0 | 0.7 ± 0.8 |
| Irregular (22) | 16.3 ± 8.8 | 0.40 ± 0.20 | 6.2 ± 9.6 | 1.9 ± 2.5 |
| Dystonics (37) | 18.1 ± 12.2* | 0.23 ± 0.16* | 28.7 ± 21.8* | 25.5 ± 13.1* |
| Bursty (20) | 21.0 ± 15.6 | 0.09 ± 0.05 | 37.2 ± 24.9 | 32.1 ± 14.9 |
| Irregular (14) | 13.4 ± 7.8 | 0.41 ± 0.20 | 13.2 ± 16.2 | 14.2 ± 12.0 |
| ENTOPEDUNCULAR NUCLEUS (N = 4 CONTROLS, 5 DYSTONICS) | ||||
| Normals (45) | 39.1 ± 14.5 | 0.59 ± 0.26 | 9.3 ± 17.9 | 2.1 ± 2.6 |
| Regular (25) | 48.7 ± 19.8 | 0.74 ± 0.17 | 10.6 ± 20.3 | 2.0± 4.2 |
| Irregular (17) | 19.0 ± 6.9 | 0.36 ± 0.19 | 7.4 ± 13.9 | 2.1 ± 3.7 |
| Dystonics (50) | 10.1 ± 6.2* | 0.09 ± 0.18* | 33.7 ± 41.7* | 21.9 ± 22.2* |
| Bursty (20) | 13.2 ± 5.5 | 0.03 ± 0.01 | 68.1 ± 42.4 | 40.4 ± 20.8 |
| Irregular (26) | 8.6 ± 6.7 | 0.13 ± 0.23 | 7.2 ± 8.7 | 7.7 ± 8.3 |
aSubcategory designations (regular, irregular, bursty) are exclusive of outliers which did not meet criteria for one of the two common types identified for each nucleus for dystonics and controls.
bAsymmetric index (mode ISI/mean ISI) equals 1 when an ISI histogram fits a Gaussian distribution.
cBursts were detected using the interval method.