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. 2011 Aug 29;208(9):1757–1765. doi: 10.1084/jem.20102170

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© 2011 Amrani et al.

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Figure 1. — Paf is necessary for proper HSC and progenitor development. (A) FACS of thymocytes from Paf^+/+ and Paf^−/− mice stained for intracellular PAF. (B) Total number of cells in BM, thymuses, and spleens of Paf^+/+ and Paf^−/− mice. (C) Representative staining profiles for BM HSC and progenitor populations. (D and E) Absolute cell numbers in the BM of 8-wk-old (D) or 6-mo-old (E) Paf^+/+ and Paf^−/− mice. (F) Representative staining profiles and absolute number of CLPs in the BM of 8-wk- and 6-mo-old mice. Plots are gated for Lin⁻Sca-1^lowc-kit^low cells as defined in (C). (G) Representative staining profiles and absolute cell numbers of ETPs in the thymus of 8-wk-old mice. (H) Representative staining profiles for myeloerythroid progenitors. LS⁻K cells (defined in C) were subdivided into CMPs, GMPs, and MEPs as indicated. (I and J). Absolute cell numbers of LS⁻Ks, CMPs, GMPs, and MEPs in the BM of 8-wk-old (I) or 6-mo-old (J) mice. Each symbol represents a mouse combined from 3–6 experiments. Horizontal bars indicate the mean. Numbers in parentheses are the fold change of cell numbers for Paf^−/− relative to Paf^+/+ mice. *, P < 0.05; **, P < 0.01; ***, P < 0.001.