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. 2011 Aug 29;208(9):1749–1756. doi: 10.1084/jem.20110578

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© 2011 Bertossi et al.

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Figure 2. — Roquin deficiency in T lymphocytes leads to CD8 effector–like T cell expansion. (A) Relative MFI of ICOS expression on CD4 T cell subsets in the spleens of mice of the indicated genotypes. Naive, CD25⁻CD44^loCD62L^hi; effector (E)-like, CD25⁻CD44^hiCD62L^lo; memory (Mem)-like, CD25⁻CD44^hiCD62L^hi. Bars indicate medians of four mice per group, and ICOS levels on CD4cre control T cell subsets are set to 1. (B) Representative contour plots of T cell (TCR-β⁺) subsets gated as indicated on the right. Numbers represent percentages of the gated populations of the indicated T cell subtype. (C) Histogram of KLRG1 and Tbet expression on CD44^hiCD62L^lo-gated effector-like CD8 T cells, representative of five experiments. (D) Bar charts of absolute numbers of indicated T cell (TCR-β⁺; subsets as in A) and myeloid cell subsets: Eos, eosinophils (Gr1^intSiglecF⁺); Mono/Mac, monocytes/macrophages (SiglecF⁻Gr1^intMac1⁺). Columns and error bars indicate means ± SD calculated from six to nine mice per genotype. (E) Absolute numbers of splenic germinal center (GC; B220⁺PNA^hiFas^hiCD38^lo) B cells of 11–6 mice per genotype. Bars indicate the median. *, P < 0.05; **, P < 0.001; one-way ANOVA.