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. 2011 Aug 29;208(9):1901–1916. doi: 10.1084/jem.20110866

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© 2011 Tagliani et al.

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Figure 6. — Origin of uterine Mϕs and DCs. (A) Fate of adoptively transferred Ly6C^hi Mos. Pregnant CD45.2 mice on E4.5 were injected with Ly6C^hi bone marrow Mos from CD45.1 CX3CR1^GFP donors. 5 or 6 d later, donor cells were identified as being CD45.1⁺ GFP⁺ (top left) before visualization of their blood/tissue partitioning and MHCII expression status (bottom left). The percentage of extravascular (ev; blue) or intravascular (iv; orange) donor-derived cells in each tissue layer that had become Mϕs or CD11b^hi DCs is shown within the two gated populations in the top right and middle right plots. The bottom right plots show the surface phenotype of the endogenous population of extravasated leukocytes (i.e., CD45⁺ cells that are negative for i.v. anti-CD45) in each tissue layer. Data are representative of n = 4 mice from two independent experiments. (B) Mϕ and DC tissue densities in the E9.5–10.5 myometrium of Flt3L^−/− pregnant mice. n = 4–8 mice per group from six independent experiments. (C) Pre-DC and Ly6C^hi Mo abundances in the blood of Flt3L^−/− mice. n = 3–7 mice per group from six independent experiments. Error bars indicate SEM.