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. 2011 Aug 29;208(9):1835–1847. doi: 10.1084/jem.20110571

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© 2011 Boulday et al.

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Figure 6. — Timing of ablation determines endothelial response to CCM2 loss. Control and iCCM2 animals were injected with tamoxifen to delete Ccm2 at P1 (left, n = 25 in each group, analyzed between P8 and P10), at 3 wk of age (middle, n = 4 in each group, from 3 different litters) or at E14.5 during gestation (right, n = 8 from 4 different litters). (A) Control and iCCM2 brains upon dissection. (B) Isolectin-B4 staining on control and iCCM2 retinas. Note the CCM lesion in the P1-induced animal (asterisks). V, vein. Bars: 2 mm (A, left and middle); 500 µm (A [right] and B [left]); 100 µm (B, right).