Figure 8.

Organization and dynamics of the MuA tetramer. Transpososome complexes for each stage of the transposition reaction are shown. The complex in brackets depicts a hypothetical transition involving a movement of DNA components within the active sites that must occur prior to strand transfer. Because this transition must occur for the efficient progression from cleavage to strand transfer, it is placed between these two steps in the reaction pathway. However, the point along the reaction pathway at which this transition occurs is unknown. The end-type DNA-binding domain (oval) and catalytic core (circle) of the L1 and R1 bound subunits are indicated.