Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2011 Sep 5;194(5):705–720. doi: 10.1083/jcb.201103103

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2011 Peterson et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 7. — Chromosomal DNA DSB resection in M phase. DNA DSBs generated in S phase are resected via the concerted action of MRN-CtIP and two additional pathways represented here as a single Exo1-DNA2 entity. S-phase resection generates ssDNA-RPA, which is competent for Rad51 filament assembly, a necessary step for HR. In contrast, DSBs generated in M phase are processed into ssDNA-RPA intermediates that do not support Rad51 chromatin assembly. Cdk1 promotes resection by phosphorylating CtIP while at the same time inhibiting Rad51 chromatin assembly. Resection initiation is dependent on MRN-CtIP in M phase as reflected by the relative size of the resection machinery components. M-phase resection generates ends that are not compatible for repair by NHEJ or by HR. These ends could be substrates for microhomology-mediated end joining in M or G1 phase. Alternatively, they could be transmitted to the next S phase and repaired by HR. P, phosphorylation.