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. 2011 Sep 5;194(5):689–703. doi: 10.1083/jcb.201105143

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© 2011 Boyd et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 8. — p53 nucleolar control and dual-export model. Results suggest that MDM2 promotes monoubiquitylation of p53 in the nucleoplasm and that mono–Ub-p53 is exported via the SIE pathway (a possible consequence of this export may be p53 movement to mitochondria). When MDM2 localizes in nucleoli, p53 is polyubiquitylated, and this modification promotes export (SSE) and proteasomal degradation of p53. The proposed points of action of factors that lead to p53 stabilization are indicated. p53 may also be degraded by nuclear proteasomes.