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. 2011 Aug 10;31(32):11578–11586. doi: 10.1523/JNEUROSCI.2266-11.2011

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Copyright © 2011 the authors 0270-6474/11/3111578-09$15.00/0

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Figure 4. — a, b, IL-1β protein levels in hippocampus (a) and liver (b) 4 d after immune challenge in animals that were housed with a running wheel, a locked wheel, or no wheel for 6 weeks. Means ± SEM are plotted. a, Hippocampus. There was a significant main effect of physical activity (sedentary, locked, runners), F_(2,35) = 6.11, p > 0.005, a significant main effect of immune challenge (vehicle, E. coli), F_(1,35) = 15.21, p < 0.0005, and a significant physical activity × immune challenge interaction, F_(2,35) = 3.57, p < 0.05. Fisher's post hoc tests showed that all vehicle-treated rats exhibited comparable IL-1β protein levels, and did not differ across conditions. Sedentary E. coli-treated IL-1β levels (n = 5) were significantly higher compared with their vehicle controls (p < 0.01; n = 6), E. coli-treated locked-wheel rats (p < 0.05; n = 5), and E. coli-treated runners (p < 0.0005; n = 8). Hippocampal IL-1β levels of locked-wheeled E. coli-treated rats were also significantly higher compared with their vehicle-treated controls (p < 0.005; n = 6) and E. coli-treated runners (p = 0.05). IL-1β levels in E. coli-treated runners were not different from their vehicle-treated controls (p = 0.73; n = 11). b, Liver. There was a significant main effect of physical activity, F_(2,36) = 5.18, p < 0.05, a significant main effect of immune challenge, F_(1,36) = 41.98, p < 0.0001, and a significant physical activity × immune challenge interaction, F_(2,36) = 6.05, p < 0.005. Again, all vehicle-treated rats exhibited comparable IL-1β protein levels, and did not differ across activity conditions. However, IL-1β levels in sedentary E. coli-treated rats (n = 7) were significantly higher compared with their vehicle controls (p < 0.0005; n = 7), E. coli-treated locked wheel rats (p < 0.05; n = 4), and E. coli-treated runners (p < 0.05; n = 8). Liver IL-1β levels of locked wheel E. coli-treated rats were also significantly higher compared with their vehicle-treated controls (p < 0.0001; n = 5), but not different from E. coli-treated runners (p > 0.05). Liver IL-1β levels in E. coli-treated runners were also significantly higher compared with their vehicle-treated controls (p < 0.001; n = 11).