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. Author manuscript; available in PMC: 2012 May 24.
Published in final edited form as: Adv Funct Mater. 2011 May 24;21(10):1754–1768. doi: 10.1002/adfm.201002468

Figure 2. Heparin non-covalently incorporated into hydrogels controls heparin-binding growth factor release and enhances tissue regeneration in vivo.

Figure 2

(A) Schematic representation of non-covalent binding of heparin GAGs within a hydrogel biomaterial presenting a heparin-binding domain. (B) Release profile of nerve growth factor from unmodified (■) and heparin-modified (●) fibrin matrices. Reproduced with permission from[96] 2000 Elsevier. (C) Heparin-modified fibrin matrices loaded with neurotrophin-3 promote extension of neural processes (red) across the glial scar border (white) at a spinal cord lesion site. Reproduced with permission from[100] Wiley Interscience 2009.