Figure 4.

The synergistic defects of boz din mutants are suppressed in boz din;swr (bmp2b) mutants. Because swr is epistatic to din (Hammerschmidt et al. 1996b), the phenotype of swr and din;swr and likewise of boz;swr and boz din;swr were identical. papc expression in (a) wild type, (b) boz din, (c) swr (or din;swr), and (d) boz din;swr (or boz;swr) at 2–4 somites. (*) Position of the tailbud. six3 (fb), pax2.1 (mhb), and krox20 (R3 and R5 ) expression in (e) wild type, (f) boz din, (g) swr (or din;swr), and (h) boz din;swr (or boz;swr). (a–d), Dorsal views, anterior to top; (e–h), dorso-anterior views; (s), somites; (n) notochord; (tb) tailbud; (fb) forebrain; (mhb) midbrain-hindbrain boundary; (R3) rhombomere 3; (R5) rhombomere 5. Bar, 100 μm.