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Model of control of neuronal differentiation via cell cycle length and Ngn2 phosphorylation. Phosphorylation of Ngn2 protein occurs in rapid progenitor cell cycles. Cell cycle lengthening results in an accumulation of un(der)phosphorylated Ngn2, enhancing promoter binding and resulting in the activation of downstream target genes that drive differentiation. E, E protein; Ub, ubiquitin; P, phosphorylation.
