Table 1. Estimates of RGC are shown in a hypothetical case of a patient with sudden onset of glaucoma at 50 years.

Onset age 50 years	50	51	52	53	55	60	70	80
Hypothetical % RGC apoptosis (rat OHT model)	0.3	1.151	15.38	12.65	6.687	1.95	1.95	1.95
RGC count based on glaucoma 4% RGC loss/year ( × 103)	1000	960	922	885	815	665	442	290
RGC count based on glaucoma loss due to apoptosis ( × 103)	1000	996	989	894	611	407	328	264
Estimated RGC apoptosis/year	3000	11 467	152 121	113 092	40 876	7934	6387	5142
Estimated glaucoma RGC apoptosis/day (DARC count)	8	31	416	309	112	22	17	14
Estimated normal 0.3% RGC apoptosis/day	8	8	8	8	8	8	8	7

The RGC apoptosis count estimates are calculated from extrapolating the profile from the rat OHT model (Figure 2). Both yearly and daily (DARC count) levels of predicted RGC apoptosis are given in a hypothetical glaucoma case and compared with estimates of age-matched normal.