Table 5.

Effect of choice of control group on association statistics for 4 known pancreatic cancer risk SNPs

SNP/odds ratio/minor allele frequency		Control datasets
		SAGE	CGEMS prostate cancer	CGEMS breast cancer	CIDR PD and SIALS
	Controls, n:	1,487	1,350	1,344	1,065
rs505922/	rank	6,769	2,866	1,131	481
1.2/	p value	0.02	0.01	0.004	0.0018
0.358	power	0.333	0.328	0.32	0.315
rs9543325/	rank	21	101	133	445
1.26/	p value	8.2 × 10−5	0.0004	0.0004	0.001
0.317	power	0.483	0.477	0.476	0.459
rs3790844/	rank	7,645	84,087	20,488	92,396
0.77/	p value	0.02	0.31	0.075	0.34
0.21	power	0.49	0.491	0.491	0.476
rs401681/	rank	239,819	244,531	77,059	173,589
1.19/	p value	0.91	0.94	0.28	0.64
0.434	power	0.313	0.308	0.308	0.297

Analytical power is computed assuming an additive model with α = 0.05.