Table 1.
Patient characteristics of the intent-to-treat populationa
| Characteristic | ASAQ (n = 184) |
AL (n = 182) |
p-value |
|---|---|---|---|
| Sex, n (%) | |||
| Male | 102 (55.4) | 98 (53.8) | 0.76b |
| Age, years | |||
| Mean ± SD | 11.94 ± 10.52 | 11.75 ± 9.17 | 0.67c |
| Range | 0.8-65.0 | 1.2-60.0 | |
| <12 years, n (%) | 101 (54.9) | 100 (54.9) | 0.99b |
| Weight, kg | |||
| Mean ± SD | 29.55 ± 16.11 | 31.08 ± 17.34 | 0.59c |
| Range | 9.0-89.0 | 7.6-77.2 | |
| BMI, kg/m2 | |||
| Mean ± SD | 14.87 ± 3.11 | 14.99 ± 3.22 | 0.58c |
| Range | 10.0-29.7 | 9.8-27.4 | |
| Parasite density, asexual forms/μl | |||
| Geometric mean | 32383.9 ± 37362 | 31713.7 ± 37253 | 0.716c |
| Range | 1034-195764 | 1016-195837 | |
| Gametocyte carriers, n (%) | 7 (3.8) | 2 (1.1) | 0.174d |
| Blood haemoglobin, g/dL | |||
| Mean ± SD | 10.9 ± 2.3 | 10.8 ± 2.5 | 0.85e |
| Range | 5.8-15.8 | 5.5-18.2 |
aAll randomized patients receiving at least one dose of study drug (patients vomiting twice after receipt of first dose were excluded); bChi2 test; cWilcoxon rank test; dFisher's exact test; eStudent t-test.