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. 2008 Nov 10;2008(1):308623. doi: 10.1155/2008/308623

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Copyright © 2008 Linzhong Li et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Model for the hepatic plate. A line of hepatic cells is bidirectionally coupled by gap junctions. Heterogeneity of the hepatocytes is controlled by the structure parameter defined as the ratio of the effective volume of the ER to the effective cytosolic volume. The concentration of InsP3 is denoted by . denotes the concentration of cytoplasmic-free calcium in cell . represents the coupling coefficient as defined by the scaled gap junction permeability. The model is based on Höfer's calcium oscillation model in hepatocytes [17].

Inline graphic — Model for the hepatic plate. A line of hepatic cells is bidirectionally coupled by gap junctions. Heterogeneity of the hepatocytes is controlled by the structure parameter defined as the ratio of the effective volume of the ER to the effective cytosolic volume. The concentration of InsP3 is denoted by . denotes the concentration of cytoplasmic-free calcium in cell . represents the coupling coefficient as defined by the scaled gap junction permeability. The model is based on Höfer's calcium oscillation model in hepatocytes [17].