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. 2011 Sep 12;6(9):e24535. doi: 10.1371/journal.pone.0024535

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Ang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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H₂S has been demonstrated to be overproduced in sepsis. H₂S stimulation of TRPV1 and the downstream release of SP lead to the activation of ERK_1/2, which subsequently induces the phosphorylation and degradation of IκBα, as well as the translocation and activation of NF-κB, thereby leading to SIRS and MODS characteristic of severe sepsis. indicates exogenous administration; indicates inhibition.

Inline graphic — H₂S has been demonstrated to be overproduced in sepsis. H₂S stimulation of TRPV1 and the downstream release of SP lead to the activation of ERK_1/2, which subsequently induces the phosphorylation and degradation of IκBα, as well as the translocation and activation of NF-κB, thereby leading to SIRS and MODS characteristic of severe sepsis. indicates exogenous administration; indicates inhibition.