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. 2011 Sep 12;6(9):e24774. doi: 10.1371/journal.pone.0024774

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Guo et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A. Mice were inoculated with 1×10⁷ CFU of S. aureus to induce infection. Survival of WT (n = 15), plg^-/- (n = 16) and plg^+/- (n = 15) mice was followed for 25 days. Significant differences were found between WT and plg^-/- mice (log-rank test, P<0.05). B. Mice were inoculated with 1.6×10⁸ CFU of S. aureus to induce sepsis. Survival of WT (n = 28), tPA^+/-/uPA^+/- (n = 10), tPA^-/- (n = 13), uPA^-/- (n = 15), plg^+/- (n = 20), plg^-/- (n = 10), and tPA^-/-/uPA^-/- (n = 7) mice was followed for 8 days. Significant differences were found between WT mice and plg^-/- mice (log-rank test, P<0.01).