Vascular defects in E9.5 Arnt−/− placentas. H&E-stained Arnt+/+ (A,B) and Arnt−/− (C,D) sections showing the presence of a chorionic plate (short arrows in A and C) in both animals, but lack of fetal vessels (long arrows in B) in the labyrinthine layer of the Arnt−/− placenta (D). Original magnification in A,C: 80×; magnification of inset in B,D: 400×. (GC) Giant cells; (MD) maternal deciduum; (LT) labyrinthine trophoblast.