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. 2000 Dec 15;14(24):3191–3203. doi: 10.1101/gad.853700

Figure 6.

Figure 6

Rescue of Arnt−/− placental defects by aggregation of Arnt−/−ES cells with tetraploid wild-type morulas that provide functional extraembryonic tissues. (A–D) E9.7 tetraploid embryo ⇔ ES cell chimeras generated with either Arnt+/+ ES cells (A,B) or Arnt−/− ES cells (C,D) and green fluorescent protein–tagged wild-type tetraploid embryos. Yolk sacs are shown in B and D, whereas embryos dissected free of their yolk sacs are shown in A and C. (E–H) E10.6 chimeras generated with Arnt+/+ and Arnt−/− ES cells. Note the abnormal yolk sac vasculature exhibited by Arnt−/− chimeras at both E9.7 (D) and E10.6 (H).