Figure 7.

Immunofluorescence of β1. Control: Like α1, β1-IR was also only present in the basolateral membranes of all acinar and ductal cells, and numerous punctate staining within the cytoplasm. However, levels of β1-IR differed in a “mosaic” pattern, higher in some acinar cells and/or acini (arrowheads) than others. β1-IR in ductal cells was uniformly higher (arrow). These data were similar to our previous report [13]. IAD: like in control animals, β1-IR was also present in all acinar cells and demonstrated a similar “mosaic” pattern (arrowheads). Ducts also showed a much higher β1-IR (arrow). No significant difference of β1-IR was observed between control and IAD animals. Scale bar=50 μm.