Table 1.

Fold-activation of HDAC-8 by 10 μM concentration of selected N-acetylthiourea derivatives

Entry	Structure	Compound ID	Fold-Activationa
1		TM-2-51	12
2		TM-2-87	2
3		TM-2-88	8.4
4		TM-2-138	3.5
5		TM-2-97	5.6
6		TM-2-105	2.0
7		TM-2-90	3.3
8		TM-2-101	1.1
9		TM-2-104	4.5
10		TM-2-130	1.5
11		TM-2-131	3.0
12		TM-2-126	1.2
13		TM-2-125	1.1
14		TM-2-107	3.0
15		TM-2-139	1.0

^aDefined as the ratio of the initial rate of the HDAC-8 catalyzed reaction in the absence and presence and of 10 μM activator