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. Author manuscript; available in PMC: 2012 Sep 12.
Published in final edited form as: ACS Comb Sci. 2011 Jul 28;13(5):486–495. doi: 10.1021/co200057n

Figure 3.

Figure 3

Top (a) and side view (b) of the overall FKBP12-rapalog 11b complex. FKBP12 is rendered as a surface with a probe radius of 1.4 Å and rapalog is in a licorice representation with hydrogen atoms omitted for clarity. C, O and N atoms are colored in cyan, red, and blue, respectively. (c) Stereo view of the complex between FKBP12 (shown in silver color except for the O and N atoms involved in binding) and rapalog 11c [color scheme: C (cyan), O (red), and N (blue)]. Dash lines indicate intermolecular hydrogen bonding, electrostatic, and CH-π interactions between the rapalog and the active-site residues of FKBP12.