Skip to main content
. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Pharm Res. 2011 Jun 15;28(10):2599–2609. doi: 10.1007/s11095-011-0489-3

Fig. 2.

Fig. 2

Significant enhancement of fenretinide solubility in simulated saliva (pH 6.8) by non-ionic surfactants, bile salts, phospholipid, and novel amphiphilic polymer. Effect of co-incorporation of 0.5–5%w/v bile salts (a: sodium deoxycholate (●), sodium cholate (○), sodium glycocholate (△), and sodium taurocholate (◊)), nonionic surfactants (b: Brij® 35 (●), Brij® 98 (○), Tween® 20 (▲), and Tween® 80 (■)), novel polymeric solubilizer (c: Soluplus®), and phospholipid (d: lecithin) on the solubility of fenretinide in simulated saliva. Studies were conducted in amber color ampoules under evacuated conditions at 37°C and symbols represent mean ± SE, n = 3.