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Persistent expression of NICD results in increases in mRNA levels of Notch targets. (A) Construct and mating scheme for activated NICD expression in Pomc-expressing cells. (B) Activated NICD results in modest increases in canonical target mRNA levels in Tg (gray bars) pituitaries as compared to control (black bars) at e16.5. n=3–5. *:p<0.05.
