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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Bioorg Med Chem Lett. 2011 Aug 3;21(19):5831–5834. doi: 10.1016/j.bmcl.2011.07.105

Scheme 3.

Scheme 3

Reagents and conditions: (i) 3-chloro-3-methyl-1-butyne, KOH in EtOH, N2; (ii) N,N-diethylaniline, reflux; (iii) K2OsO2(OH)4, (DHQ)2-PHAL, K3Fe(CN)6, K2CO3 in t-butanol/H2O (v/v=1:1), ice bath; (iv) (S)-camphanic chloride, DMAP in CH2Cl2.