. Author manuscript; available in PMC: 2012 Oct 1.

Published in final edited form as: Bioorg Med Chem Lett. 2011 Aug 3;21(19):5831–5834. doi: 10.1016/j.bmcl.2011.07.105

Table 1.

Anti-HIV-1 NL4-3 data of analogues 5–8 in TZM-bl cells^a

Compound	CC₅₀ (μM)	EC₅₀ (μM)	TI
5a	4.55	0.030	153
5b	-	-	NS
6a	1.84	0.038	48.0
6b	3.83	0.184	20.8
7a	5.4	0.054	100
7b	-	-	NS
8a	>30.6	0.128	>238
8b	>30.6	8.59	>3.6
2-Ethyl-DCP	14.3	0.12	119

All data presented in this table were averaged from at least three independent experiments. EC₅₀: concentration that inhibits NL4-3 replication by 50%. CC₅₀: concentration that inhibits uninfected TZM-bl cell growth by 50%. TI = CC₅₀/EC₅₀. NS: there was no inhibition at concentrations below the CC₅₀.