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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Bioorg Med Chem Lett. 2011 Aug 11;21(19):5711–5714. doi: 10.1016/j.bmcl.2011.08.032

Scheme 1.

Scheme 1

Reagents and conditions: (i) (a) oxalyl chloride, CH2Cl2, DMF cat., rt, 2 h; (b) aminopyridine, CH2Cl2, Et3N, rt; (ii) aminopyridine, BOP, i-Pr2EtN, DMF, rt, 16h; (iii) methyl iodide, CH2Cl2 or MeOH, 2–7 d; (iv) m-CPBA, CH2Cl2, 16 h.