Table 2.
WT (23) | PAPP-A KO (17) | ΔH19/KO (15) | ΔH19/WT (29) | |
---|---|---|---|---|
Midshaft | ||||
Cort th | 0.288 ± 0.009 | 0.246 ± 0.009* | 0.235 ± 0.006* | 0.284 ± 0.005 |
Area | 1.49 ± 0.05 | 1.01 ± 0.04* | 1.12 ± 0.03* | 1.44 ± 0.03 |
BMC | 1.56 ± 0.06 | 1.03 ± 0.05* | 1.10 ± 0.04* | 1.56 ± 0.04 |
BMD | 1047 ± 23 | 1027 ± 19 | 989 ± 25 | 1091 ± 15 |
Distal metaphysis | ||||
Area | 4.30 ± 0.13 | 3.38 ± 0.11* | 3.63 ± 0.09 | 4.60 ± 0.10 |
BMC | 2.21 ± 0.08 | 1.55 ± 0.08* | 1.62 ± 0.07 | 2.10 ± 0.05 |
BMD | 519 ± 9 | 455 ± 11* | 444 ± 14* | 462 ± 6* |
Cort th: Cortical thickness (mm).
Area: (mm2).
BMC: Bone mineral content (per 1 mm slice).
BMD: Bone mineral density (mg/cm3).
Results are mean ± SEM, with numbers of mice per group in parentheses.
Significantly different from WT, P < 0.05.