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. Author manuscript; available in PMC: 2012 Sep 15.
Published in final edited form as: Bioorg Med Chem. 2011 Jul 28;19(18):5507–5519. doi: 10.1016/j.bmc.2011.07.043

Scheme 1.

Scheme 1

Reagents and conditions: (a) TBDMSCl/imidazole/DMAP/CH2Cl2/rt; (b) H2/Pd-C/(Boc)2O/Et3N/EtOH/rt; (c) MsCl/Et3N/CH2Cl2/rt; (d) TBAF/THF/rt; (e) BocNHCH(CH2CH2SH)CO2t-Bu/LDA/DMF; (f) (i) TFA, (ii) TFA/H2O.