Figure 2.
Representative correlations between global cognitive z-score and subcortical brain volumes. Significant correlations were found in the amydala (left: r=0.22, p=0.01; right: r=0.23, p=0.01, not shown), cerebral white matter (left: r=0.28, p=0.001; right: r=0.24, p=0.005, not shown), thalamus (left: r=0.23, p=0.006, not shown; right: r=0.24, 0=0.005) and hippocampus (left: r=0.21, p=0.01, not shown; right: r=0.24, p=0.005). Note that HIV subjects with or without HAND had similarly smaller range of brain volumes relative to SN subjects, but only HAND subjects had poorer global z-scores than the other two groups. SN subjects had similar volumes and cognitive z-scores as the HIV+NC subjects. However, for each region, the slopes of the trend lines in relation to morphometric measures were similar across the 3 groups. Similar trends were observed in other brain structures. All p-values and partial correlations are adjusted for eTIV.