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Design and Synthesis of Cyclic Peptide Library against Cn.
Reagents and conditions: a) standard Fmoc/HBTU chemistry; b) soak in water; c) 0.5 equiv. Fmoc-OSu in Et2O/CH2Cl2; d) Di-tert-butyl dicarbonate; e) piperidine; f) 4-hydroxymethylbenzoic acid (Hmb)/HBTU/HOBt; g) Fmoc-β-Ala-OH/DIC; h)TFA; i) split-and-pool synthesis by Fmoc/HATU chemistry; j) Pd(PPh3)4; and k) PyBOP, HOBt.
