Table 1.
Cyclic Peptides Identified from Library Screening against Cn
| Bead No. | Peptide Sequences |
KD (μM)
|
|
|---|---|---|---|
| Single-bead | Resynthesized | ||
| 10 | Tyr-His-Ile-Gly-D-Leu-Gly-Pro-Val-Ile-Val-Ile-Thr-Ala-Ala-Glu | 0.92 ± 0.37 | 8.4 ± 2.8 |
| 113 | Nle-D-Pro-Pip-Arg-D-Ala-D-Ala-Pro-Val-Ile-Val-Ile-Thr-Gly-Ala-Glu | 1.6 ± 0.3 | |
| 25 | Nle-Gly-Tyr-D-Ala-Arg-D-Pro-Pro-Val-Ile-Val-Ile-Thr-Ala-Ala-Glu | 1.9 ± 0.3 | 7.6 ± 4.8 |
| 67 | Gly-Orn-Phg-Gly-Ala-Pro-Val-Ile-Val-Ile-Thr-Gly-Ala-Ala-Glu | 2.1 ± 0.9 | |
| 82 | D-Leu-Arg-Arg-Ile-Gln-D-Pro-Pro-Val-Ile-Val-Ile-Thr-Ala-Ala-Glu | 2.4 ± 0.6 | 1.6 ± 0.3 |
| 88 | D-Lys-D-Thr-Ser-Arg-Arg-D-Pro-Pro-Val-Ile-Val-Ile-Thr-Gly-Glu | 2.6 ± 1.8 | |
| 108 | Tyr-Nle-Orn-Arg-Gln-Ala-Pro-Val-Ile-Val-Ile-Thr-Gly-Ala-Ala-Glu | 2.8 ± 0.8 | |
| 84 | Arg-Arg-D-Leu-Ile-Arg-Pip-Pro-Val-Ile-Val-Ile-Thr-Ala-Ala-Glu | 3.0 ± 0.7 | 0.74 ± 0.35 |
| 104 | D-Nal-Arg-D-Val-D-Asn-Gln-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Ala-Glu | 3.0 ± 0.8 | |
| 33 | D-Ala-D-Leu-D-Asn-D-Lys-Phg-D-Ala-Pro-Val-Ile-Val-Ile-Thr-Glu | 3.3 ± 0.6 | |
| 24 | D-Lys-Gln-D-Phe-Gln-D-Leu-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Ala-Ala-Glu | 3.4 ± 1.0 | |
| 18 | D-Lys-D-Val-Arg-Pip-D-Glu-D-Pro-Pro-Val-Ile-Val-Ile-Thr-Ala-Ala-Glu | 3.5 ± 1.0 | |
| 86 | Gly-Asp-Arg-Ala-Arg-Gly-Pro-Val-Ile-Val-Ile-Thr-Gly-Ala-Glu | 3.8 ± 1.4 | 30 ± 20 |
| 14 | D-Nal-Phg-His-His-His-Pro-Val-Ile-Val-Ile-Thr-Ala-Ala-Glu | 3.8 ± 0.9 | |
| 94 | D-Lys-Gln-Arg-Ala-D-Thr-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Ala-Ala-Glu | 4.4 ± 0.8 | |
| 21 | D-Glu-D-Val-D-Pro-D-Pro-D-Ala-D-Pro-Pro-Val-Ile-Val-Ile-Thr-Gly-Ala-Ala-Glu | 4.8 ± 1.2 | |
| 61 | Ala-Orn-D-Nal-Ser-D-Glu-Ala-Pro-Val-Ile-Val-Ile-Thr-Glu | 5.4 ± 3.0 | 16 ± 5 |
| 11 | Ser-D-Pro-His-Gly-Pip-Pro-Val-Ile-Val-Ile-Thr-Gly-Ala-Ala-Glu | 5.7 ± 2.2 | |
| 79 | D-Thr-D-Ala-Arg-Nle-Arg-Gly-Pro-Val-Ile-Val-Ile-Thr-Glu | 20 ± 12 | |