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Ribonuclease protection in isolated telomerase complexes. Isolated telomerase complexes were footprinted separately as in Fig. 5. RNase V1 footprints of the 280-(A), 550- (B), and 1600-kD (C) complexes are shown. Lane designations are as in Fig. 5. The position of nucleotide 109 is indicated with an arrowhead. For each panel, equivalent amounts of sequencing ladder were loaded and the exposures were adjusted until the signals of full-length RNA were approximately the same.
