Table 3.

Summary of studies investigating the effects of the FAAH inhibitor URB597 or genetic deletion of FAAH on anxiety-like and depression-like behavior in rodents.

Authors	Animals	Drug	Doses and route	Test	Anxiety	Depression
Kathuria et al. (2003)	Sprague-Dawley rats	URB597	0.1 mg/kg, IP	Elevated 0 maze	↓
Kathuria et al. (2003)	Sprague-Dawley rats (pups)	URB597	0.1 mg/kg, IP	Isolation induced USVs	↓
Gobbi et al. (2005)	Sprague-Dawley rats	URB597	0.1 mg/kg, IP	Tail suspension test		↓
Gobbi et al. (2005)	Sprague-Dawley rats	URB597	0.1 mg/kg, IP	Forced swim test		↓
Gobbi et al. (2005)	Sprague-Dawley rats	URB597	0.1 mg/kg, IP (repeated 4 days)	Forced swim test		↓
Adamczyk et al. (2008)	Wistar rats	URB597	0.1–0.3 mg/kg, IP	Forced swim test		↓
Bambico et al. (2010)	FAAH KO mice (C57BL6/6J)	N/A	N/A	Tail suspension test		↓
Bambico et al. (2010)	Mice, FAAH KO (C57BL6/6J)	N/A	N/A	Forced swim test		↓
Bortolato et al. (2007)	Wistar rats	URB597	0.3 mg/kg IP (repeated 5 weeks)	Sucrose consumption after chronic mild stress		↓
Hill et al. (2007)	Long–Evans rats (ovariectomized female + estradiol treatment)	URB597	0.1 mg/kg, IP	Forced swim test		↓
Realini et al. (2011)	Sprague-Dawley rats (females + 10 days THC treatment)	URB597	0.3 mg/kg IP (repeated 30 days)	Forced swim test		↓
Realini et al. (2011)	Sprague-Dawley rats (females + 10 days THC treatment)	URB597	0.3 mg/kg, IP (repeated 30 days)	Sucrose consumption		↓
Wright et al. (2010)	Sprague-Dawley rats (DFP treated)	URB597	3 mg/kg, IP	Forced swim test	=
McLaughlin et al. (2007)	Sprague-Dawley rats	URB597	0.5 and 1 μg (hippo campus)	Forced swim test	=
Manna and Jain (2011)	Swiss mice	URB597	0.05–10 μg/mouse, ICV	Forced swim test		↓
Moise et al. (2008)	Syrian hamsters	URB597	0.1–0.3 mg/kg, IP	EPM	↓
Moise et al. (2008)	Syrian hamsters	URB597	0.3–3 mg/kg, IP	Conditioned and unconditioned social defeat test	=
Moreira et al. (2008)	C57BL/6N mice	URB597	10 mg/kg, IP	EPM	↓
Patel and Hillard (2006)	ICR mice	URB597	0.1–0.3 mg/kg, IP	EPM	↓
Lisboa et al. (2008)	Wistar rats	URB597	0.01 nmol, IC (dorsal periaqueductal gray)	Vogel conflict test	↓
Rubino et al. (2008)	Sprague-Dawley rats	URB597	0.1 μg/rat	EPM	↓
Scherma et al. (2008)	Sprague-Dawley rats	URB597	0.1–0.3 mg/kg, IP	Light–dark test	↓
Naderi et al. (2008)	NMRI mice	AM404	1–2 mg/kg, IP	EPM	↓
Naderi et al. (2008)	NMRI mice	URB597	0.03–0.3 mg/kg, IP	EPM	=
Micale et al. (2009)	C57BL/6J mice	URB597	1 mg/kg, IP	EPM	↓
Micale et al. (2009)	C57BL/6J mice	URB597	0.1–0.5 mg/kg, IP	EPM	=
Naidu et al. (2007)	C57BL/6J-ICR mice	URB597	0.3–1–3 mg/kg, IP	EPM	=
Naidu et al. (2007)	C57BL/6J-ICR mice	URB597	10 mg/kg, IP	EPM	=
Naidu et al. (2007)	C57BL/6J-ICR mice	URB597	0.1 mg/kg, IP	Modified EPM	↓
Naidu et al. (2007)	FAAH KO mice (C57BL/6J)	N/A	N/A	EPM	=
Naidu et al. (2007)	FAAH KO mice (C57BL/6J)	N/A	N/A	Tail suspension test		=
Naidu et al. (2007)	C57BL/6J mice	URB597	0.1–10 mg/kg, IP	Tail suspension test		=
Naidu et al. (2007)	FAAH KO mice (C57BL/6J)	N/A	N/A	Modified tail suspension test		↓
Naidu et al. (2007)	C57BL/6J mice	URB597	0.1 mg/kg, IP	Modified tail suspension test		↓
Seillier and Giuffrida (2011)	Wistar rats	URB597	0.1, 0.3, 1 mg/kg, IP	EPM	=
Haller et al. (2009)	Sprague-Dawley rats	URB597	0.1–0.3 mg/kg, IP	EPM (low aversiveness)	=
Haller et al. (2009)	Sprague-Dawley rats	URB597	0.1–0.3 mg/kg, IP	EPM (high aversiveness)	↓

EPM, elevated plus-maze. For effects in models of anxiety and depression, ↓ indicates impairment; ↑ indicates enhancement; = indicates no effect.