Figure 9.

Model of Wnt-induced villin protein expression in adenocarcinoma-derived HT29 cells and fetally derived, untransformed human intestinal epithelial cells. Wnt5a interaction with Ror2 is mediated by the cysteine-rich domain. Phosphorylation of the tyrosines within in the Ser/Thr-1 region, possibly by Src, induces ERK1/2 phosphorylation. Stimulated ERK1/2 upregulates villin transcript expression; this subsequently increases villin protein. This Wnt5a-induced villin expression is also mediated by CK1. As well, CDX2, acting downstream of, or in parallel with, the activated ERK1/2 MAPK cascade could be mediating Wnt5a-induced increases in villin protein.