Table 6.
Genotype and allele frequencies of RPSA 5-UTR -8T>C polymorphism according to the PRNP codon 129 or 219 status
| PRNP 129 | Healthy controls (n = 189) | Sporadic CJD patients (n = 180) | P-value1 | P-value2 | ||||
|---|---|---|---|---|---|---|---|---|
| MM (n = 180) | MV (n = 9) | VV (n = 0) | MM (n = 180) | MV (n = 0) | VV (n = 0) | |||
| Genotype frequency, n (%) | ||||||||
| TT | 84 (46.7) | 7 (7.8) | - | 87 (48.3) | - | - | ||
| TC | 75 (41.7) | 2 (2.2) | - | 78 (43.3) | - | - | 0.233 | 0.570 |
| CC | 21 (11.6) | 0 (0) | - | 15 (8.3) | - | - | ||
| Allele frequency | ||||||||
| T | 0.68 | 0.89 | - | 0.70 | - | - | 0.057 | 0.469 |
| C | 0.32 | 0.11 | - | 0.30 | - | - | ||
| PRNP 219 | Healthy controls (n = 189) | Sporadic CJD patients (n = 180) | P-value3 | P-value4 | ||||
| EE (n = 173) | EK (n = 16) | KK (n = 0) | EE (n = 180) | EK (n = 0) | KK (n = 0) | |||
| Genotype frequency, n (%) | ||||||||
| TT | 86 (49.7) | 5 (31.3) | - | 87 (48.3) | - | - | ||
| TC | 68 (39.3) | 9 (56.3) | - | 78 (43.3) | - | - | 0.338 | 0.600 |
| CC | 19 (11.0) | 2 (12.4) | - | 15 (8.3) | - | - | ||
| Allele frequency | ||||||||
| T | 0.69 | 0.59 | - | 0.70 | - | - | 0.244 | 0.854 |
| C | 0.31 | 0.41 | - | 0.30 | - | - | ||
1Difference in healthy controls with MM and healthy controls with MV.
2Difference in healthy controls with MM and sporadic CJD patients with MM.
3Difference in healthy controls with EE and healthy controls with EK.
4Difference in healthy controls with EE and sporadic CJD patients with EK.