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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Synthesis (Stuttg). 2011 Sep 1;2011(17):2743–2750. doi: 10.1055/s-0030-1260112

Table 2.

Synthesis of 1,2,5-Thiadiazepane 1,1-Dioxides

graphic file with name nihms311382t2.jpg
Entry R1 R2 Product Yield (%)
1 MeO n-C8H17 5b 65
2 H n-Bu 5c 74
3 H 4-FC6H4CH2 5d 69
4 Cl 4-MeOC6H4CH2 5e 82
5 Cl PhCH2CH2 5f 77
6 F i-Bu 5g 65
7 CF3 Bn 5h 79
8a Me c-C5H9 5aa 60a
9a H n-Bu 5ca 71a
a

Performed using the following MACOS conditions: 3a/3c (1.0 equiv), DBU (1.0 equiv), amine (1.2 equiv), i-PrOH (0.3 M), 75 µL/min, 100 °C, 130 W.