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. 2011 Jun 16;219(3):410–417. doi: 10.1111/j.1469-7580.2011.01405.x

Fig. 2.

Fig. 2

Expression of MUC1, 3, and 4 in developing human salivary glands. (A1–A4) Initial bud: (A1,A2) Minimal expression of MUC1 in the epithelial cords (arrows). (A3,A4) No MUC3 or 4 at this stage of glandular development. Original magnification: ×400. (B1–B3) Pseudoglandular stage: (B1) MUC1 in the luminal space of canalizing structures. (B2) Mucin MUC3 – diffuse expression in the cytoplasm of epithelial cells. Expression of this mucin was also observed in blood vessel walls (arrows). (B3) Weak expression of MUC4 mainly in the luminal space of the ductal system and in blood vessel walls (arrows). Original magnification: ×400 (B1), ×600 (B2), and ×250 (B3). (C1–C3) Canalicular stage: (C1) Strong expression of MUC1 in the luminal spaces of the ductal system. (C2) Weak expression of MUC3 in ductal cell cytoplasm, mainly in the basal pole. (C3) Weak expression of MUC4 in the luminal pole of ducts and in blood vessel walls (arrows). Original magnification: ×150 (C1), ×600 (C2), and ×400 (C3). (D1–D4) Terminal bud: (D1,D2) Strong expression of MUC1 in the luminal space of the ductal system and in the basal pole of excretory duct cell cytoplasm. (D3) Expression of MUC3 in the cytoplasm of ductal cells and in some demilune structures. (D4) Presence of MUC4 in blood vessel walls (arrows) and in the luminal space of excretory ducts. Original magnification: ×600 (D1), ×150 (D2), ×400 (D3), ×400 (D4).