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. Author manuscript; available in PMC: 2012 Feb 26.
Published in final edited form as: Immunity. 2011 Aug 26;35(2):249–259. doi: 10.1016/j.immuni.2011.08.008

Figure 6. CD8α+ dendritic cells are the only cells whose IL-12 production is protective against acute T. gondii infection.

Figure 6

BALB/c chimeras and control non-chimeric mice were infected with T. gondii and monitored for survival (A) and parasite burden (B–C). (A) Survival data from non-chimeric wild-type (black line) and Batf3−/− (red line) mice were compared to lethally irradiated recipients which received only wild-type (purple line) or Batf3−/− (green line) BM, or a 1:1 mixture of wild-type with Batf3−/− BM (orange line) or Il12a−/− with Batf3−/− BM (blue line) (n=5–6, representative of 2 independent experiments). Parasite burden (B) and representative images (C) on day 7 after infection from the groups in (A). (B) Horizontal lines represent the geometric mean. **: 0.001<P<0.01, ***: P<0.001.